Sinotech Healthy Co., Ltd. （中科康的）is a hightech enterprise focus on biomatrerials of regenerative medicine, which is based on the close cooperation between industry, University and Research Institute. Its main R&D members leaded by Prof. Peibiao Zhang, are from the research group of regenerative medical materials (再生医学材料课题组）, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences.
They started the research of regenerative medicine from 2000. It is the first scientific research team in China named after "regenerative medical materials" (in 2014), engaged in the research of biomedical polymer materials, recombinant growth factors, and their medical application in the fields of tissue engineering and regenerative medicine for more than 20 years.
The team has been supported by nearly 40 funds of national, ministerial and local projects, including the National "863 Program" Project, the special project for international cooperation of Ministry of Science and Technology, the CAS-JSPS joint research program, key projects for the opening up of military logistics, the National Natural Science Foundation, the "double ten" major scientific and technological research projects in Jilin Province, and key projects for the transformation of academic and local achievements, with a total of more than 20 million scientific research funds.
The team members have published more than 150 scientific papers in well-known international journals in the biomedical interdisciplinary field, such as Adv Func Mater, Bioact Mater, Biomaterials, Biomacrolecules, et al. Among them, there are 49 papers with if>5, 12 papers with if>10, and the highest SCI impact factor of a single paper is 19. More than 50 Chinese patents were applied and more than 30 were authorized.
 |  |
| (2021, IF=19.924 ) | (2021, IF=16.874) |
 |  |
| (2021, IF=16.744) | (2009, IF=15.304) |
 | |
| (2016,IF=11.092) |
1. Design, expression and purification of recombinant proteins
2. Design and synthesis of biodegradable polymers
3. Blending and modification of high performance polymer materials
4. Design and preparation of micro-nano materials
5. Design and preparation of tissue engineering scaffolds
6. Biological modification and immobilization technology on material surface
7. Design and preparation of multifunctional hydrogel materials for hemostasis and antibacterial
8. Research and development of regenerative repair materials for bone, skin, nerve and cornea, et al.
So far, the total number of instruments and equipment in Changchun Chemical Institute has reached 11730. The total amount of equipment is 661million yuan. Among them, 241 sets of equipment with more than 500000 yuan are worth 323million yuan. 118 sets of equipment above 1million yuan, valued at 238million yuan. It mainly includes general large-scale equipment, repair and purchase equipment and laboratory instruments and equipment based on the spectral center.
2. The ultra clean synthesis laboratory and synthesis processing equipment of the research group include: fume hood (made in China), rotary evaporator (made in China), super purification glove box (Mikrouna), supercritical high-pressure fluid pump (model sfc-24, USA) and high-pressure reactor (made in China), muffle furnace (bf51732c-1, thermo, USA), torque rheometer (Shanghai), mBot 3D printer (made in China), etc.
|
|
|
|
|
|
|
|
|
3. The research group also has various biological and medical research instruments and equipment:
(1) Thousand grade (local hundred grade) ultra clean cell culture room;
(2) Carbon dioxide incubator (Heraeus, Germany, 2 sets; Sanyo, Japan, 1 set);
(3) Fluorescent inverted microscope (Nikon te2000-u);
(4) Ultra low temperature refrigerator (thermo forma, USA);
(5) Automatic microplate reader (multiskan MK3, USA);
(6) Low temperature high-speed centrifuge (sigma, 3K30);
(7) Frozen tissue slicer (Leica cm1900, Germany);
(8) PCR instrument (bio rad, USA);
(9) Electrophoresis (bio rad, USA);
(10) Gel imaging system (UVP biochemihr, USA);
(11) Fluorescent real-time quantitative PCR instrument (stratagene MX 3005p, USA);
(12) Full wavelength scanning multifunctional reader (TECAN infinite m200, Switzerland);
(13) Laser confocal microscope (Zeiss LSM 780, Germany);
(14) Fluorescence ortho microscope (Zeiss Axio imager A2, Germany);
(15) High temperature sterilization pot (ldzx-501cbs, domestic);
(16) Constant temperature incubator (dnp-9082, domestic);
(17) Suspension three-dimensional culture device (four position micro stirrer+double wall culture bottle, Wheaton, USA)
(18) Tc-3 mechanical stress stimulated bioreactor (Spain)
(19) Vacuum freeze dryer (made in China);
(20) Vacuum drying oven (domestic);
 | | | |
| | | |
| |
| |
4. Self-made research equipment by the research team:
(1) Melt rotary disk spinning device (self-made): used to prepare polymer micro-nano non-woven fibers.
(2) Electrical stimulation culture device (self-made): used to study the effect of pulsed electrical signal stimulation on cell growth and differentiation on the material surface.
(3) Electromagnetic stimulation culture device (self-made): used to study the effect of pulsed electromagnetic signal stimulation on cell growth and differentiation on the material surface.
5. The research team’s pilot production research equipment in the High-tech North District:
(1) A 1,681-square-meter pilot incubation base, including a 900-square-meter GMP clean production workshop.
(2) Nanofiber electrospinning machine (YT-MS-I, Shanghai): It adopts needle-free electrospinning technology with spiral electrodes and can continuously produce non-woven polymer micro-nano fiber mats with a width of 30 cm.
(3) Centrifugal two-fluid dual-purpose spray dryer (QFN-LE-5, Shanghai): Uses centrifugal or two-fluid to achieve rapid spray drying of materials. It has a wide particle size range (adjustable from nanometer to 160 microns) and is suitable for high-temperature spray drying. Rapid preparation of particles (spheres) of molecular or inorganic materials.
(4) 10L fully automatic biological fermentation system: used for high-density fermentation of E. coli to produce genetically engineered recombinant proteins.
(5) Torque rheometer (XSS-300, Shanghai): 2~120r/min (stepless) frequency conversion speed regulation. Temperature control range, room temperature ~ 400℃, suitable for most polymer blending and extrusion molding.
6. "Regenerative Medicine" regional center large-scale instrument platform: The research team is responsible for the large-scale instrument platform of the 13th Five-Year Plan of the Ministry of Finance, purchasing a total of 10.5 million instruments and equipment for molecular level, tissue level and overall animal level detection and analysis.
(1) Quadrupole-electrostatic field orbitrap mass spectrometer-mass spectrometry imaging combined system:
(2) Cell (in situ, panoramic, high-throughput) quantitative analysis system:
(3) Small animal micro CT in vivo:
(4) Unique CD system tomography workstation:
(5) Particle size and shape meter:
(6) Frozen slicer: