Recently, the research team's basic research work on the application of bone tissue engineering materials - namely "Basic Research on Structural Interface Control and Application of Bone Tissue Engineering Materials", won the 2021 "Second Prize of Jilin Provincial Natural Science Award". This work started in 2003 and was completed in nearly 15 years under the guidance of Academician Chen Xuesi and Researcher Jing Xobin. It was supported by the National Natural Science Foundation of China project "Hydroxyapatite nanocomposites with bone grafted with polylactic acid on the surface." Tissue Engineering" (50673090) and "Polypeptide-modified mesoporous nanohydroxyapatite/polylactic acid composite materials and biomedical applications" (51273195), National Natural Science Foundation of China Youth Fund "Preparation of functional polypeptide-modified polymer materials" and its application in bone tissue engineering" (51403197), Jilin Province's "Double Ten Project" major scientific and technological research project "Research on key technologies for the industrialization of absorbable nanocomposite artificial bone materials and devices" (20130201005GX) and other projects support, A series of research results have been achieved.

The development of biodegradable medical polymers as bone tissue engineering materials for the fixation and repair of bone injuries has become a current research hotspot at home and abroad, and its structural design and interface regulation are key factors affecting bone regeneration. In response to this key scientific issue, this project proposed and developed L-polylactic acid (PLLA) self-modified bioactive nano-hydroxyapatite (HA), and polylactic acid-polyglycolic acid copolymer (PLGA) with adjustable degradation rate. A universal preparation method for preparing bone tissue engineering materials by mixing and preparing composite materials, and introducing small molecule active peptides into the interior or surface of the materials through copolymers or DOPA molecules, revealing the key structural and interface factors and regulatory mechanisms that affect bone formation, and ultimately A series of new synthetic bone tissue engineering materials that can guide or induce bone formation have been developed.

The work content mainly includes:

1. Material composition, structure and physical and chemical interface control. 1. From the perspective of bionics (the composition and structure of natural bone), we designed and prepared oligolactic acid (LAc oligomer) self-modified nanohydroxyapatite (op-HA) and PLGA composite materials, and obtained the microscopic view of bone tissue engineering scaffolds. Structural and biological property correlations. 2. Op-HA/PLGA composite scaffolds with different oligolactic acid grafting rates (1.1, 5.2, 9.1%) were prepared, and the impact of grafting amount on the interfacial compatibility, physical and chemical properties and biological properties of the material was revealed. 3. It was found that the incorporation of op-HA nanoparticles can also affect the surface topology of the scaffold material, thereby affecting the biological performance, and is closely related to the content and grafting rate of op-HA.

2. Construction and precise control of biological functional interfaces. 4. Using PLLA as the basic skeleton, an amphiphilic triblock copolymer mPEG-PLA-PBGL containing RGD small peptides was designed and prepared, and a biodegradable polymer material with enhanced cell adhesion was obtained, which was used to prepare a stable RGD interface. laid the foundation for bone tissue engineering scaffolds; 5. Innovatively established the "homogeneous modification" method of RGD peptide for bone tissue engineering scaffolds, and gained a deep understanding of RGD peptide copolymers and bone morphogenetic protein 2 (BMP-2). )'s respective roles and synergies. 6. By immobilizing more than two small molecule active peptides (collagen mimetic peptide P15 and bone peptide OGP) on the surface of mussel bionic pDA molecules, a simple, easy and promising method for surface modification of bone scaffolds was established. When P15 and OGP are combined, it not only promotes cell adhesion and growth of the material, but also significantly increases the expression level of osteogenic differentiation genes.

The research work of this project has published a total of 38 papers, including 33 SCI papers and 11 authorized patents. Among them, 5 representative papers have been positively cited by SCI 319 times, and they have given more than 50 oral or invited presentations at important international and domestic conferences. These achievements have enriched the construction, structure, interface control and medical applications of bone tissue engineering materials. They have been highly praised and widely cited by international and domestic peers, and have promoted the transformation of related technical achievements and product development.