Massive hemorrhage is a concern in civilian accidents such as military trauma and surgery, and uncontrolled hemorrhage is the leading cause of prehospital death. Reducing patient suffering and mortality is an urgent issue. An ideal hemostatic agent should have effective antimicrobial properties. At present, a variety of hemostatic materials such as hemostatic particles, gauze, and hemostatic hydrogel have been studied for rapid and effective hemostasis. However, traditional hemostatic agents cannot meet the requirements for bleeding from deep wounds, abdominal surgeries and puncture wounds. We used a melt spinning method to prepare a biodegradable polylactic acid bionic cotton fiber mat. Sodium alginate (SA) was fixed on the fiber surface through dopamine (DA) from mussel byssus, and Fe3+ was chelated with alginic acid carboxyl groups and dopamine phenolic hydroxyl groups, and loaded into PLA cotton. Material hemostatic performance: The hemostatic time in vitro is 47 s. When used to stop hemorrhage in rat liver, the bleeding volume is 0.097 g and the hemostatic time is 23 s. Due to its strong hydrophilicity and fluffy cotton-like structure, it can absorb a large amount of water from the blood, which can concentrate blood components and reduce clotting time. It also exhibits good antibacterial properties against Escherichia coli and Staphylococcus aureus. It is worth noting that it has superior blood compatibility, cell compatibility and tissue compatibility, therefore, it has high application potential in clinical hemostasis. This work has applied for a Chinese invention patent and was published in Bioactive Materials, a journal founded by Keai Publishing. The SCI impact factor is 14. The article title is: "