In 2020, the research team obtained two more authorized patents in the preparation methods of 3D printing materials and bioadhesives.

First, a method for preparing 3D printed flexible porous scaffold materials was invented (Patent No.: 2019106252600). This method uses one or more polyester materials among PLA, PLGA, PCL and PC as the 3D printing ink, and one or more organic solvents among NMP, DMF and DMSO as the solvent for the printing ink. The principle of 3D printing and solvent replacement curing is used to obtain 3D printed flexible porous scaffold materials at room temperature through fiber accumulation and connection. The advantages of this 3D preparation method are (1) energy saving and non-melting or freezing 3D printing method; (2) carried out at normal or low temperature, which is conducive to the loading of growth factors, drugs and other active substances; (3) material selection It has the characteristics of wide range, simple preparation process, good flexibility and sutureability, and the fiber surface has a micro-nano pore structure, which is conducive to cell adhesion and proliferation. The 3D printed flexible porous scaffold can be used as artificial skin and other soft tissue repair materials and patches for tissue regeneration and repair.

Second, a smart bioadhesive was invented. It has the structure shown in formula (I); in formula (I), 1≤x≤6, 8≤y≤32, 25≤z≤65, 2≤n≤10. The adhesive is a ternary random copolymer with good adhesion. It can be applied to most surfaces including various biological tissues. The bonding strength and affinity of the product can be adjusted by changing the proportion of structural units. Water-based; at the same time, this smart bioadhesive also has good biodegradability, blood compatibility, biocompatibility and tissue regeneration induction ability, and can be used for the adhesion of osteoblasts and other tissue cells, and improves Its proliferation and differentiation capabilities; more importantly, the smart bioadhesive provided by the present invention also has conductivity and electrical activity. After applying pulsed electrical stimulation, it can further promote the proliferation and differentiation of tissue cells such as osteoblasts, and is suitable for Adhesion and regeneration repair after bone and other tissue damage.